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XL784
- Development stage
- Phase 2
- Lead developer
- Exelixis
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
XL784 is a potent small molecule inhibitor of the ADAM-10 metalloprotease enzyme, developed by Exelixis. It was designed to selectively inhibit ADAM-10 and matrix metalloproteinase 2 (MMP-2), while sparing MMP-1, which may enhance its safety profile compared to other metalloprotease inhibitors. The drug acts as an angiogenesis inhibitor and has demonstrated efficacy in preclinical models for reducing aortic dilatation and proteinuria. XL784 was investigated primarily for diabetic nephropathies (including albuminuria) and cancer, with clinical trials reaching Phase II before development was discontinued[1][2][4][7].
02
Targets
MMP-2 (Matrix metalloproteinase-2)ADAM10 (Disintegrin and metalloproteinase domain-containing protein 10)ADAM17 (A disintegrin and metalloprotease 17)MMP13 (Matrix metalloproteinase-13)MMP9 (Matrix metalloproteinase-9)
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