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XLS-104
- Development stage
- Preclinical
- Lead developer
- Xiangxue Precision Medical Technology
- Modality
- TCR-Engineered T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
XLS-104 is an investigational T-cell receptor engineered T-cell (TCR-T) therapy developed by Guangdong Xiangxue Precision Medical Technology (XLifeSc). It is designed to target the KRAS G12D neoantigen, a common driver mutation in various solid tumors, including pancreatic, colorectal, and lung cancers. The therapy involves engineering a patient's T cells to express a specific TCR that recognizes the KRAS G12D peptide presented by the HLA-A*11:01 molecule. This recognition triggers the specific killing of tumor cells harboring the mutation. XLS-104 is currently in the preclinical stage of development for the treatment of multiple solid tumors.
- Other names
- KRAS G12D-TCR-T cell therapy
02
Targets
KRASG12D (Kirsten rat sarcoma viral oncogene homolog (KRAS) G12D mutant)pMHC-I (Peptide–MHC class I complex)
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