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XMMME-001-DTPA 111 Indium

Development stage: Preclinical
Lead developer: XOMA
Modality: Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics
Administration: Intravenous

Overview

**XMMME-001-DTPA 111 Indium** is an experimental indium-111 radiolabeled murine antimelanoma monoclonal antibody developed for diagnostic imaging of systemic and nodal melanoma metastases. The XMMME-001 antibody component recognizes high-molecular-weight melanoma-associated antigens, while the DTPA chelator complexes indium-111, enabling gamma-camera and single-photon emission computed tomography detection of antibody-localized tumor sites. It is a diagnostic radioimmunoconjugate rather than the related ricin A-chain immunotoxin XMMME-001-RTA.

Other names: Antimelanoma antibody XMMME-001-DTPA 111 Indium

Targets

CSPG4 (Chondroitin sulfate proteoglycan 4)

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