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Drug intelligence / Profile preview
XMMME-001-DTPA 111 Indium
- Development stage
- Preclinical
- Lead developer
- XOMA
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Gamma Emitters → Radiopharmaceuticals, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
**XMMME-001-DTPA 111 Indium** is an experimental indium-111 radiolabeled murine antimelanoma monoclonal antibody developed for diagnostic imaging of systemic and nodal melanoma metastases. The XMMME-001 antibody component recognizes high-molecular-weight melanoma-associated antigens, while the DTPA chelator complexes indium-111, enabling gamma-camera and single-photon emission computed tomography detection of antibody-localized tumor sites. It is a diagnostic radioimmunoconjugate rather than the related ricin A-chain immunotoxin XMMME-001-RTA.
- Other names
- Antimelanoma antibody XMMME-001-DTPA 111 Indium
02
Targets
CSPG4 (Chondroitin sulfate proteoglycan 4)
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