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XP-103

Development stage: Preclinical
Lead developer: Xynomic Pharmaceuticals Holdings
Modality: Small Molecules
Administration: Topical

Overview

**XP-103** is a small molecule dual inhibitor targeting tropomyosin receptor kinases (TRK/NTRK) and Fra-1 (Fos-related antigen 1), transcription factors involved in oncogenesis and tumor progression. Developed by Xynomic Pharmaceuticals, it is designed for oncology applications, particularly solid tumors driven by NTRK fusions or Fra-1 overexpression. The compound remains in early preclinical development, specifically the lead optimization stage, as part of Xynomic's pipeline focused on kinase inhibitors for cancer therapy.[1][3][5][7]

Targets

NTRK3 (Tropomyosin receptor kinase C)FOSL1 (FOS-like antigen 1)NTRK2 (Tropomyosin-related kinase receptor type B)NTRK1 (Tropomyosin-related receptor kinase A)

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