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XPACE-1009
- Development stage
- Preclinical
- Lead developer
- Xanadu Bio
- Modality
- mRNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Nanoparticles → Drug Delivery Systems
01
Overview
XPACE-1009 is an investigational mRNA-based therapeutic being developed by Xanadu Bio for the treatment of non-small cell lung cancer (NSCLC). The drug utilizes Xanadu Bio's proprietary PACE (poly(amine-co-ester)) polymer nanoparticle platform to deliver mRNA encoding Interleukin-2 (IL-2) and Interleukin-12 (IL-12) specifically to lung tissue. By inducing the local expression of these potent cytokines, XPACE-1009 is designed to modulate the tumor microenvironment and stimulate a robust anti-tumor immune response. It is currently in the IND-enabling/preclinical stage of development, with the PACE platform allowing for potential systemic or local administration routes tailored for organ-specific targeting.
02
Targets
IL-2 (Interleukin 2)IL12 (Interleukin-12)
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