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XTR025

Development stage: Unknown
Lead developer: Sinotau Pharmaceutical Group
Modality: Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Peptides
Administration: Intravenous

Overview

XTR025 is a targeted radiopharmaceutical candidate developed by Sinotau Pharmaceutical Group for the imaging and potential treatment of Glypican-3 (GPC3)-expressing malignancies, primarily hepatocellular carcinoma (HCC). GPC3 is a cell-surface oncofetal protein that is highly overexpressed in HCC but has minimal expression in healthy adult tissues, making it a highly specific biomarker for liver cancer. XTR025 consists of a GPC3-targeting peptide ligand conjugated to a radionuclide, such as Gallium-68 (68Ga) for positron emission tomography (PET) imaging. This allows for high-sensitivity detection, staging, and monitoring of GPC3-positive lesions. The platform is also amenable to theranostic applications, where the imaging isotope can be replaced with a therapeutic isotope like Lutetium-177 (177Lu) to deliver targeted radiation directly to tumor cells.

Other names: 68Ga-XTR02568Ga-GPC3-targeted radiopharmaceutical

Targets

GPC3 (Glypican-3)

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