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XTS001

Development stage: Preclinical
Lead developer: X-tosis
Modality: Small Molecules

Overview

XTS001 is a small molecule inhibitor of Voltage-dependent anion channel 1 (VDAC1) oligomerization being developed by X-tosis for the treatment of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. By preventing the oligomerization of VDAC1, XTS001 aims to restore mitochondrial function and prevent mitochondrial-mediated cell death, which is a key driver in neurodegeneration. The drug is currently in the IND-enabling phase of development.

Targets

VDAC1 (Hexokinase 2–voltage-dependent anion channel 1 complex)

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