Drug intelligence / Profile preview

xuebijing

Development stage
Phase 4
Lead developer
Tianjin Chase Sun Pharmaceutical
Administration
Intravenous
01

Overview

Xuebijing is a traditional Chinese medicine (TCM) injection developed by Tianjin Chase Sun Pharmaceutical for the treatment of sepsis, systemic inflammatory response syndrome (SIRS), and multiple organ dysfunction syndrome (MODS). It is a complex botanical extract derived from five medicinal herbs: *Carthamus tinctorius* (safflower), *Paeonia lactiflora* (red peony root), *Ligusticum chuanxiong* (chuanxiong), *Salvia miltiorrhiza* (danshen), and *Angelica sinensis* (dang-gui). The drug functions by inhibiting the cytokine storm associated with severe infection, specifically targeting pro-inflammatory mediators such as TNF-α, IL-1β, IL-6, and HMGB1. Additionally, it helps regulate the coagulation system and improves microcirculation. Xuebijing is widely used in intensive care units in China and gained international attention for its inclusion in the national clinical guidelines for the treatment of COVID-19.

Brand names
Xuebijing
Other names
Xuebijing InjectionXBJ
02

Targets

ENO (Alpha-enolase)HMGB1 (High mobility group protein B1)IL1B (Interleukin-1 beta)IL-6 (Interleukin 6)KEAP1 (Kelch-like ECH-associated protein 1)PBK (TOPK)PKM2 (Pyruvate kinase M2 isoform)TNFA (Tumor necrosis factor alpha (soluble))

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