Drug intelligence / Profile preview

Xuezhatai

Development stage
Unknown
Lead developer
Changsha Innovative Traditional Chinese Medicine Modernization Research Institute
Modality
Small Molecules
Administration
Oral
01

Overview

Xuezhatai is a Traditional Chinese Medicine (TCM) formulation developed by the Changsha Innovative Traditional Chinese Medicine Modernization Research Institute and manufactured by Hunan Warrant Pharmaceutical. It is primarily indicated for the treatment of hyperlipidemia, specifically cases classified under the TCM syndrome of phlegm-stasis obstruction. The drug is a modernized herbal preparation composed of six key ingredients: *Crataegus pinnatifida* (Hawthorn), *Polygonum multiflorum* (He Shou Wu), *Alisma plantago-aquatica* (Ze Xie), *Nelumbo nucifera* (Lotus leaf), *Senna tora* (Cassia seed), and *Rheum palmatum* (Rhubarb). Pharmacologically, Xuezhatai acts by regulating lipid metabolism, which includes the inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase to reduce endogenous cholesterol synthesis, as well as promoting the excretion of lipids and inhibiting the absorption of exogenous fats. Clinical application has shown it effectively lowers total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C) while potentially increasing high-density lipoprotein cholesterol (HDL-C).

Brand names
Xuezhatai
Other names
Xuezhatai Capsule血脂泰
02

Targets

LDLR (Low-density lipoprotein receptor)PPARA (Peroxisome proliferator-activated receptor alpha)HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)

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