Drug intelligence / Profile preview

Xuzhou Medical Univ. V2R compound 25

Development stage
Unknown
Lead developer
Xuzhou Medical University
01

Overview

Xuzhou Medical Univ. V2R compound 25: sourced facts only. name: "Among these derivatives, compound 25 exhibited potent binding affinity to the V2R (Ki = 9.0 ± 1.5 nM) and efficacious cAMP inhibition (IC50 = 9.2 ± 3.0 nM)." [PMID:35579344]; target: "Among these derivatives, compound 25 exhibited potent binding affinity to the V2R (Ki = 9.0 ± 1.5 nM) and efficacious cAMP inhibition (IC50 = 9.2 ± 3.0 nM)." [PMID:35579344]; developer: "Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou 221004, Jiangsu, China." [PMID:35579344]; stage: "Further advancing compound 25 in a murine model of ADPKD demonstrated a significantly improved in vivo efficacy compared with the reference compound tolvaptan." [PMID:35579344]

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