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XW10508 MR
- Development stage
- Phase 2
- Lead developer
- XWPharma
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
XW10508 MR is an investigational, once-daily, extended-release oral small molecule prodrug of esketamine developed by XWPharma. It acts as a glutamatergic N-methyl-D-aspartate (NMDA) receptor antagonist and an alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor activator. The drug is designed with potential abuse-deterrent properties and is being evaluated for the treatment of major depressive disorder (MDD), including treatment-resistant depression, and chronic pain. By utilizing a prodrug approach and a modified-release formulation, XW10508 MR aims to provide sustained therapeutic levels of esketamine while minimizing the peak-related side effects and abuse potential typically associated with ketamine-based therapies.
- Other names
- XW10508 MRXW-10508 MRXW 10508 MRXW10508XW-10508XW 10508
02
Targets
AMPAR (AMPA receptor)NMDAR (Glutamate receptor ionotropic, NMDA)
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