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Xycrobes
- Development stage
- Preclinical
- Lead developer
- Revance
- Modality
- Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Gene Therapies
- Administration
- Topical
01
Overview
Xycrobes are a live biotherapeutic technology platform consisting of engineered skin-derived commensal bacteria. Developed by Xycrobe Therapeutics and acquired by Crown Laboratories, the technology is commercialized under the brand name BIOJUVE™. [8, 9] The active ingredient is a specific living strain of beneficial bacteria, *Cutibacterium acnes subspecies defendens* (strain XYCM42). [3, 7] These microbes are delivered topically, where they live on the skin and in follicles to naturally produce and deliver biotherapeutics such as proteins, antioxidants, and anti-inflammatory mediators. [2] The technology is designed to beneficially modulate the skin microbiome to treat inflammatory skin conditions and signs of aging by replacing pathogenic flora with beneficial microbes, consuming excess oil, and releasing skin-healthy molecules. [4, 6]
- Brand names
- XycrobesBIOJUVE
02
Targets
IL10RA (Interleukin-10 Receptor)
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