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Y332
- Development stage
- Unknown
- Lead developer
- Wuhan YZY Biopharma
- Modality
- Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, T-cell Engagers → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
Y332 is a bispecific antibody (BsAb) developed by Wuhan YZY Biopharma Co., Ltd., utilizing their proprietary Y-body platform. It is designed as a T-cell engager that simultaneously targets CD70, a member of the tumor necrosis factor (TNF) receptor superfamily often overexpressed in various malignancies, and CD3, a component of the T-cell receptor complex. By bridging T cells and CD70-expressing tumor cells, Y332 facilitates the activation and redirection of cytotoxic T lymphocytes to eliminate cancer cells. It is primarily being investigated for the treatment of advanced solid tumors, including renal cell carcinoma and other CD70-positive cancers, particularly in patients who have failed standard therapies.
- Other names
- CD3 x CD70 bispecific antibodyCD-3 x CD70 bispecific antibodyCD 3 x CD70 bispecific antibody
02
Targets
CD70 (Cluster of Differentiation 70)CD3 (T-cell surface glycoprotein CD3)
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