Drug intelligence / Profile preview

Yan Tiao Fang

Development stage
Unknown
Lead developer
Longhua Hospital Shanghai University of Traditional Chinese Medicine
Modality
Small Molecules
Administration
Oral
01

Overview

Yan Tiao Fang is a Traditional Chinese Medicine (TCM) herbal formula specifically developed for the management of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Primarily researched and utilized at Longhua Hospital, affiliated with the Shanghai University of Traditional Chinese Medicine, the formula is designed to address the damp-heat and blood stasis patterns identified in TCM diagnosis. Its therapeutic efficacy is attributed to its ability to modulate the immune microenvironment and suppress systemic and local inflammation. Mechanistically, Yan Tiao Fang inhibits the activation of the NLRP3 inflammasome and the NF-κB signaling pathway, leading to a significant reduction in the expression of pro-inflammatory mediators such as IL-1β, IL-6, and TNF-α. Clinical and preclinical studies suggest it effectively alleviates pelvic pain and improves urinary function in patients with refractory chronic prostatitis.

Other names
Yantiaofang炎调方
02

Targets

NF-κBNLRP3 (Nod-like receptor family pyrin domain-containing protein 3)

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