Drug intelligence / Profile preview

Yang Qing Chen Fei Granules

Development stage
Unknown
Lead developer
Henan University of Chinese Medicine
Modality
Small Molecules
Administration
Oral
01

Overview

Yang Qing Chen Fei Granules is a multicomponent Traditional Chinese Medicine (TCM) formulation developed primarily for the treatment of pneumoconiosis, specifically targeting the 'yin deficiency and heat-dryness' syndrome pattern. Developed by researchers at the Henan University of Traditional Chinese Medicine and manufactured by Sichuan Neo-Green Pharmaceutical Technology Development, the formula consists of seven key herbal ingredients: Dwarf Lilyturf Tuber (Radix Ophiopogonis), American Ginseng (Panax quinquefolius), Figwort Root (Radix Scrophulariae), Snakegourd Fruit (Fructus Trichosanthis), Thunberg Fritillary Bulb (Bulbus Fritillariae Thunbergii), Red Peony Root (Radix Paeoniae Rubra), and Turmeric Root Tuber (Radix Curcumae). Its therapeutic effects are derived from a synergistic blend of phytochemicals—such as ginsenosides and alkaloids—that exert anti-inflammatory and anti-fibrotic activities in the lungs. By inhibiting pro-inflammatory cytokines like TNF-α and IL-6 and downregulating the TGF-β1 signaling pathway, the granules aim to mitigate the diffuse lung tissue fibrosis characteristic of mineral dust exposure. Clinical trials have demonstrated its efficacy in improving exercise capacity, as measured by the 6-minute walk distance, and enhancing the health-related quality of life for patients with coal worker's pneumoconiosis.

Brand names
Yang Qing Chen Fei Granules
Other names
Yang Qing Chen FeiYang-Qing-Chen-FeiYangqing Chenfei RecipeYangqing Chenfei Formula
02

Targets

IL-6 (Interleukin 6)TGFB1 (Transforming growth factor Beta-1 proprotein)TNFA (Tumor necrosis factor alpha (soluble))IL1B (Interleukin-1 beta)

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