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Yangshenguo Guanxin Tablet
- Development stage
- Unknown
- Lead developer
- Institute of Regenerative Medicine, Jilin University
- Administration
- Oral
01
Overview
Yangshenguo Guanxin Tablet is a Traditional Chinese Medicine (TCM) formulation developed by the Institute of Regenerative Medicine at Jilin University. It is primarily indicated for the treatment of coronary artery disease and stable exertional angina pectoris, specifically targeting patients with the TCM pattern of qi and yin deficiency. The preparation is derived from the fruit of *Panax ginseng* (known as Yangshenguo in this context), which is traditionally used to tonify qi and nourish yin. The drug has been evaluated in Phase 3 clinical trials in China, where it was compared against Yixinshu Tablet to assess its efficacy in reducing angina symptoms and improving myocardial blood flow over an 8-week treatment period.
- Brand names
- Yangshenguo Guanxin Tablet
- Other names
- Yangshenguo Guanxin PianYangshenguo Guanxin Tablets
02
Targets
JUN (Transcription factor Jun)STAT3 (Signal Transducer and Activator of Transcription 3)MAPK14 (p38 mitogen-activated protein kinase alpha)IL-6 (Interleukin 6)RELA (Nuclear Factor Kappa B Subunit p65)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)TP53 (Cellular Tumor Antigen p53 R175H)EGFR T790M (Epidermal growth factor receptor T790M mutant)CASP3 (Caspase-3)
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