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Yangxin Decoction is a traditional Chinese herbal formula used primarily in Traditional Chinese Medicine (TCM) for the treatment of various cardiovascular and neuropsychiatric conditions. The specific composition of "Yangxin Decoction" can vary by clinical context and region, but it generally consists of a combination of herbs intended to "nourish the heart," calm the mind, and regulate qi and blood. In published studies, related formulas such as "Yangxin Tongquan decoction" have included ingredients like Poria (Fu Ling), Polygala (Yuan Zhi), Semen Ziziphi Spinosae (Suan Zao Ren), Fossilizid (Long Gu), Ostreae Concha (Mu Li), Magnetitum (Ci Shi), Cortex Albiziae, Salvia miltiorrhiza root, Bupleurum root, Paeonia alba root, Acorus tatarinowii rhizome, Glycyrrhiza uralensis root (licorice), among others[1]. Mechanistically, these herbal combinations are believed to exert anxiolytic effects by modulating neurotransmitter systems involved in anxiety and stress responses; some components may also influence vascular function or platelet aggregation[1][4][5]. Clinical studies suggest that certain forms of Yangxin Decoction can improve symptoms in avoidant paruresis when combined with cognitive–behavioural therapy without significant adverse effects[1], while other related formulas have been studied for unstable angina pectoris with potential benefits on blood viscosity and endothelial function[4]. The mechanism is multi-targeted due to its composite nature; network pharmacology analyses indicate possible actions on adrenergic signaling pathways, calcium signaling pathways, voltage-gated potassium channels as well as modulation of neurotransmitters relevant to mood regulation[5].
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