Yangzhengxiaoji + cyclophosphamide + doxorubicin + vincristine + prednisone

This is a combination regimen consisting of Yangzhengxiaoji, a traditional Chinese medicine formula, with four established chemotherapeutic agents—cyclophosphamide, doxorubicin, vincristine, and prednisone. - **Yangzhengxiaoji** (YZXJ) is a multi-herb traditional Chinese medicine used as an adjunct in cancer therapy. It has demonstrated anti-tumor effects by inhibiting cell migration and invasion through antagonism of the hepatocyte growth factor (HGF) receptor (cMET), disruption of angiogenesis via inhibition of focal adhesion kinase (FAK) and AKT pathways, and modulation of the PI3K/AKT signaling pathway[1][2][3][4]. YZXJ may also alleviate chemotherapy-associated symptoms and improve quality of life in cancer patients[2][4]. - **Cyclophosphamide** is an alkylating agent that crosslinks DNA to inhibit cell division. - **Doxorubicin** is an anthracycline antibiotic that intercalates DNA and inhibits topoisomerase II. - **Vincristine** is a vinca alkaloid that disrupts microtubule formation during mitosis. - **Prednisone** is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive properties. The combination aims to leverage both the direct cytotoxic effects of standard chemotherapy agents on rapidly dividing cells as well as the complementary mechanisms provided by YZXJ for enhanced antitumor efficacy.