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YB-820

Development stage: Preclinical
Lead developer: Ymmunobio
Modality: Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics
Administration: Parenteral

Overview

YB-820 (also known as YB-800BS1) is a preclinical-stage bispecific T-cell engager (BiTCE) being developed by Ymmunobio for the treatment of solid tumors. The drug is designed to target neuronal pentraxin receptor (NPTXR), a tumor-specific marker overexpressed in multiple solid tumor types, and CD3 on T cells. By simultaneously binding to NPTXR on tumor cells and CD3 on T lymphocytes, YB-820 redirects T cells to NPTXR-positive tumor cells, promoting highly selective immune-mediated tumor cell killing.

Targets

NPTXR (Neuronal pentraxin receptor)CD3 (T-cell surface glycoprotein CD3)

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