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YCH3971
- Development stage
- Unknown
- Lead developer
- Chinese Academy of Sciences
01
Overview
YCH3971: sourced facts only. name: "Among these compounds, YCH3971 exhibited potent inhibiting activity against PARP1 with an IC50 of 7.52 nM, showing a remarkable subtype selectivity compared with PARP2 (>1000-fold)." [PMID:41672027]; target: "Among these compounds, YCH3971 exhibited potent inhibiting activity against PARP1 with an IC50 of 7.52 nM, showing a remarkable subtype selectivity compared with PARP2 (>1000-fold)." [PMID:41672027]; developer: "State Key Laboratory of Drug Research, Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China; School of Pharmacy, University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing, 100049, China." [PMID:41672027]; stage: "Also, YCH3971 possessed a strong antiproliferative activity on BRCA mutant MDA-MB-436 cells with an IC50 of 2.10 nM." [PMID:41672027]
02
Targets
PARP1 (Poly (adp-ribose) polymerase 1)
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