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The yellow fever live attenuated vaccine, developed by the Beijing Institute of Biological Products (BIBP), is a prophylactic vaccine used to prevent yellow fever virus infection. It utilizes the 17D-204 attenuated strain of the yellow fever virus as its active ingredient. The production process involves inoculating the working seed into 7-8 day old SPF chicken embryos, which are then incubated, harvested, and processed into a freeze-dried formulation to ensure stability. The vaccine is designed to induce a robust and long-lasting protective immune response by stimulating the production of neutralizing antibodies and activating cellular immunity. It is primarily indicated for individuals traveling to or residing in WHO-designated yellow fever endemic regions and is listed as a mandatory vaccination by Chinese entry-exit inspection and quarantine authorities for travelers to these areas.
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