Drug intelligence / Profile preview

YH0618

Development stage
Preclinical
Lead developer
The University of Hong Kong
Administration
Oral
01

Overview

**YH0618** is an orally administered medicinal-and-edible traditional Chinese formula being investigated as supportive care for chemotherapy-induced toxicities, particularly alopecia and dermatologic adverse effects. Published descriptions of the soup preparation identify black soybean, brown rice, black fungus, and Siraitia grosvenorii fruit as its component foods; a granule-study protocol describes a related five-food formulation that includes liquorice. Preclinical studies suggest that YH0618 reduces doxorubicin-associated injury in normal liver and kidney cells through modulation of FOXO4-associated mitochondrial apoptosis signaling and may attenuate doxorubicin-induced alopecia through keratin-associated and TGF-beta/Smad3-pathway effects. It is not an approved anticancer drug and is intended to mitigate treatment toxicity rather than replace chemotherapy. ([jcancer.org](https://www.jcancer.org/v10p3665.htm))

Other names
YH0618 decoctionYH-0618 decoctionYH 0618 decoctionYH0618 granuleYH-0618 granuleYH 0618 granuleYH0618 soupYH-0618 soupYH 0618 soup

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