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YH40863
- Development stage
- Preclinical
- Lead developer
- Yuhan
- Modality
- Recombinant Proteins and Enzymes, Peptides
- Administration
- Subcutaneous
01
Overview
YH40863 is a long-acting glucagon-like peptide-1 (GLP-1) and growth differentiation factor 15 (GDF15) dual receptor agonist under development by Yuhan. It targets both the GLP-1 receptor (GLP-1R) and the GDF15 receptor (GDNF family receptor alpha-like, or GFRAL) to achieve synergistic effects on appetite suppression, body weight reduction, and glycemic control. In preclinical animal models of obesity and type 2 diabetes, YH40863 has demonstrated potent and sustained weight loss, improved lipid profiles, and enhanced glycemic control, outperforming several mono-component and dual-agonist comparators. It is being investigated for the treatment of obesity, type 2 diabetes, and metabolic dysfunction-associated steatohepatitis (MASH).
02
Targets
GFRAL (Glial-derived neurotrophic factor family receptor alpha-like/ret receptor complex)GLP1R (GLP-1R)
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