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YHP2508A
- Development stage
- Phase 4
- Lead developer
- Yuhan
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
YHP2508A is an oral, fixed-dose combination (FDC) therapy developed by Yuhan Corporation for the treatment of hypertension. It is a new formulation of Yuhan's approved three-drug combination product, Truset, which contains the calcium channel blocker amlodipine, the angiotensin II receptor blocker (ARB) telmisartan, and the thiazide-like diuretic chlorthalidone. YHP2508A is designed to improve patient compliance and therapeutic efficacy by combining three complementary mechanisms of action into a single tablet. It is currently in Phase 1 clinical development, with bioequivalence studies being conducted in healthy subjects to compare it against reference formulations.
- Other names
- amlodipine + telmisartan + chlorthalidone
02
Targets
AGTR1 (Angiotensin II Type-1 receptor)SLC12A3 (Thiazide-sensitive sodium-chloride cotransporter)CACNA1C (Voltage-dependent L-type calcium channel subunit alpha-1C)CACNA1D (Voltage-dependent L-type calcium channel subunit alpha-1D)
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