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**Yiceng** is a topical traditional Chinese medicine plaster/application used investigationally for musculoskeletal inflammatory disorders, particularly knee osteoarthritis. Its principal medicinal component is Sanse powder, a multi-herb preparation. Preclinical rat studies report reduced synovial inflammation, pain-related hypersensitivity, and synovial fibrosis, with reported associations with modulation of inflammatory mediators and PI3K/AKT/HIF-1α, AMPK, Toll-like receptor, and inflammasome-related signaling. Available evidence is primarily academic and preclinical, with limited publicly verifiable clinical-development detail.
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