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Yifei Sanjie Granule
- Development stage
- Unknown
- Lead developer
- The Third Affiliated Hospital of Henan University of Traditional Chinese Medicine
- Administration
- Oral
01
Overview
Yifei Sanjie Granule is a Traditional Chinese Medicine (TCM) formulation developed by the Third Affiliated Hospital of Henan University of Chinese Medicine for the treatment of solid pulmonary nodules. The formulation is designed to tonify lung qi and dissipate nodules, addressing the TCM pathogenesis of phlegm-stasis and qi deficiency often associated with pulmonary masses. It is currently being evaluated in prospective clinical trials to assess its efficacy in promoting nodule regression and reducing growth rates in adult patients, with outcomes measured primarily through computed tomography (CT) imaging.
- Brand names
- Yifei Sanjie Granule
- Other names
- Yifei Sanjie GranuleYifei Sanjie Keli益肺散结颗粒
02
Targets
Ubiquitin-specific protease 7 (USP7)–Nuclear receptor subfamily 1 group H member 4 (NR1H4)–bile acid metabolism axisSignal transducer and activator of transcription 3/Hypoxia-inducible factor 1-alpha/BCL2 interacting protein 3 signaling axisEpidermal growth factor receptor–p38 mitogen-activated protein kinase–Glycogen synthase kinase 3 beta–Epithelial-mesenchymal transition signaling axisCDK4 (Cyclin-dependent kinase 4)
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