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yifei sanjie wan

Development stage: Unknown
Lead developer: Guangzhou University of Chinese Medicine
Administration: Oral

Overview

Yifei Sanjie Wan (YFSJ) is a Traditional Chinese Medicine (TCM) formula primarily utilized in China for the treatment of non-small cell lung cancer (NSCLC). It is frequently employed as an adjunctive therapy to enhance the efficacy of chemotherapy (such as platinum-based doublets) and targeted agents like gefitinib or anlotinib. Mechanistically, YFSJ has been shown to inhibit the epithelial-mesenchymal transition (EMT) by modulating the EGFR/p-p38 MAPK/GSK3β signaling axis, thereby reducing tumor cell migration, invasion, and drug resistance. Additionally, it is being investigated for its potential to alleviate chemotherapy-induced cancer-related fatigue in lung cancer patients.

Other names: Yifei Sanjie RecipeYifei Sanjie PillYFSJ益肺散结丸

Targets

EGFR (Epidermal growth factor receptor)GSK3 (Glycogen synthase kinase 3 beta)MAPK14 (p38 mitogen-activated protein kinase alpha)

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