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Yigutang
- Development stage
- Preclinical
- Lead developer
- Zhejiang Provincial Administration of Traditional Chinese Medicine
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Yigutang is a Chinese herbal compound preparation primarily investigated for the treatment of osteoporosis, including senile and postmenopausal forms. It functions by promoting bone formation and inhibiting bone resorption. Its proposed mechanisms of action involve modulating key signaling pathways such as P13K/AKT/GSK-3β and Wnt/β-catenin, which leads to increased osteoblast activity, enhanced alkaline phosphatase activity, improved Ca2+ deposition, and upregulation of osteogenic markers like OCN and Runx2. Clinical and animal studies suggest that Yigutang can effectively increase bone mineral density (BMD), improve bone biomechanical properties, and elevate serum hormone levels, specifically estradiol and the estradiol/testosterone ratio, contributing to its therapeutic effects in osteoporosis. It is considered a traditional Chinese medicine and is administered orally.
- Other names
- Yigu capsuleYGCYigu decoction
02
Targets
AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)EGFR (Epidermal growth factor receptor)GLUT1 (Glucose transporter 1)HIF1A (Hypoxia-inducible factor 1-alpha)VEGFA (Vascular endothelial growth factor A)AKT (RAC-alpha serine/threonine-protein kinase)ALPL (Tissue-nonspecific alkaline phosphatase)GSK3 (Glycogen synthase kinase 3 beta)PI3K (Phosphoinositide-3-kinase regulatory subunit 6)RUNX2
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