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Yikou Sizi San

Development stage: Unknown
Lead developer: The Second Affiliated Hospital of Guangzhou University of Chinese Medicine
Administration: Topical

Overview

Yikou Sizi San is a Traditional Chinese Medicine (TCM) herbal compound used as an external hot compress treatment to promote gastrointestinal motility and recovery. It is a multi-herb formulation consisting of four primary ingredients: Fructus Evodiae (Wu Zhu Yu), Fructus Amomum tsaoko (Cao Guo), Alpiniae katsumadai (Cao Dou Kou), and Fructus Alpiniae oxyphyllae (Yi Zhi Ren). The therapy is typically applied topically to the Shenque acupuncture point (navel area) in patients suffering from postoperative gastrointestinal dysfunction (PGD), particularly following abdominal surgeries such as laparoscopic colorectal cancer surgery or laparoscopic total hysterectomy. The proposed biological mechanism under investigation involves the modulation of ghrelin signaling to enhance gastrointestinal transit. The therapy is associated with the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, where it has been evaluated in randomized controlled clinical trials.

Other names: Yikou-Sizi powder益蔲四子散

Targets

GHSR (Growth hormone secretagogue receptor)

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