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Yinhu Qingwen Granula

Development stage: Phase 3
Lead developer: China Academy of Chinese Medical Sciences
Modality: Implantable Devices → Device-based Delivery → Drug Delivery Systems, Small Molecules, Transdermal Patches → Device-based Delivery → Drug Delivery Systems, Inhalation Devices → Device-based Delivery → Drug Delivery Systems
Administration: Oral

Overview

Yinhu Qingwen Granula is a traditional Chinese medicine (TCM) herbal formulation presented in granule form. It consists of 11 common non-toxic herbs, including Polygonum cuspidatum (Japanese knotweed), Honeysuckle (Lonicera japonica), Nepeta (Schizonepeta), and Ligustrum lucidum among others[1][2][6]. The formula is designed based on TCM principles to "clear heat and detoxify," with the primary clinical use being the treatment of viral respiratory infections such as COVID-19. Preclinical studies have shown antiviral activity against SARS-CoV-2 in vivo. Clinical trials have been conducted to evaluate its efficacy and safety for mild, common, and severe COVID-19 cases; these trials are at Phase 2/3 status[1][2][6]. The mechanism of action is not fully elucidated but is presumed to involve broad immunomodulatory effects and possible direct antiviral activity.

Brand names: Yinhu Qingwen Granula
Other names: Yinhu Qingwen Decoction银花清瘟颗粒银花清瘟汤剂

Targets

ACE2 (Angiotensin-converting enzyme 2)NeuraminidaseAHR (Aryl hydrocarbon receptor)EGFR T790M (Epidermal growth factor receptor T790M mutant)Mpro (3C-like proteinase of SARS-CoV-2)HA (Hemagglutinin)NOS2 (Nitric Oxide Synthase 2)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)MPO (Myeloperoxidase)

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