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Yinma Jiedu

Development stage: Unknown
Lead developer: Guangdong Provincial Hospital of Traditional Chinese Medicine
Modality: Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration: Oral

Overview

Yinma Jiedu is a Traditional Chinese Medicine (TCM) granule formulation developed by the Guangdong Provincial Hospital of Chinese Medicine. It is primarily investigated as an adjunctive therapy to standard antibiotics for the treatment of community-acquired pneumonia (CAP). The formula is designed based on TCM principles to clear heat, detoxify, and ventilate the lungs, aiming to mitigate the inflammatory response and improve clinical recovery in patients with pulmonary infections. It is currently being evaluated in multicenter, randomized, double-blind, placebo-controlled clinical trials to establish its efficacy and safety profile in hospitalized patients.

Brand names: Yinma Jiedu
Other names: Yinma Jiedu granules银马解毒颗粒

Targets

HMGB1 (High mobility group protein B1)NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)HIF-1 (Hypoxia-inducible factor 1)HSD11B2 (11β-HSD2)

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