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Yinxielingpian
- Development stage
- Preclinical
- Lead developer
- Guangdong Provincial Hospital of Traditional Chinese Medicine
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Yinxielingpian (also known as Yinxieling tablets or Yinxie Kang tablets) is a traditional Chinese medicine (TCM) herbal formula developed by Professor Guowei Xuan at the Guangdong Provincial Hospital of Chinese Medicine. It is registered as a hospital preparation in Guangdong, China (approval No. Z20080123) and has been used for over 20 years to treat psoriasis vulgaris. The formula consists of ten herbal ingredients: Radix Rehmanniae Recen, Angelica sinensis, Radix Paeoniae Rubra, Ligusticum wallichii, Radices Lithospermi, Curcuma zedoary, Chloranthus spicatus, Rhizome Smilacis Glabrae, smoked plum, and liquorice. Yinxielingpian exerts anti-inflammatory and immunomodulatory effects, inhibiting keratinocyte proliferation and regulating the differentiation and functions of Langerhans cells via the TGF-β1/PU.1/IL-23 signaling pathway.
- Other names
- Yinxie Kang tabletsYinxiekangYinxiekang PianYinxielingYinxieling tablets银屑康片银屑灵片
02
Targets
IL-23 (Interleukin-23)IL8 (C-X-C Motif Chemokine Ligand 8)PPARG (Peroxisome proliferator-activated receptor gamma)STAT3 (Signal Transducer and Activator of Transcription 3)TGFB1 (Transforming growth factor Beta-1 proprotein)TNFA (Tumor necrosis factor alpha (soluble))
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