Drug intelligence / Profile preview

Yiqi Huazhuo Decoction

Development stage
Preclinical
Administration
Oral
01

Overview

Yiqi Huazhuo Decoction is a traditional Chinese medicine (TCM) herbal formula used primarily for the management of metabolic and cardiovascular diseases. It is composed of multiple Chinese herbs designed to "invigorate qi" (vital energy) and "remove turbidity," reflecting TCM principles. Clinical studies indicate that it can reduce blood glucose, glycated hemoglobin, body weight, and insulin resistance in patients with type 2 diabetes mellitus[1]. The decoction has also been studied for its effects on chronic heart failure when combined with conventional Western therapies[3]. Mechanistically, it appears to act through multi-target pathways including improving endothelial function, reducing inflammation and oxidative stress, modulating apoptosis-related signaling (such as AKT1 and RAS pathways), enhancing insulin secretion from pancreatic beta cells, and protecting organ tissues from injury[1][3][5]. Its composition may include herbs such as Astragalus membranaceus (Huangqi), Angelica sinensis (Danggui), licorice root (Gancao), among others—though exact ingredients can vary by formulation.

Brand names
Yiqi Huazhuo Decoction
Other names
Yiqi Huazhuo Tang益气化浊汤YD
02

Targets

HRAS (H-Ras protein)ACSL4 (Acyl-CoA synthetase long-chain family member 4)IP3R1 (Inositol 1,4,5-trisphosphate receptor 1)TP53 (Cellular Tumor Antigen p53 R175H)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)FFAR1 (Free fatty acid receptor 1)

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