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Yiqi Huoxue Huatan
- Development stage
- Phase 3
- Lead developer
- Peking University People's Hospital
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Yiqi Huoxue Huatan is a Traditional Chinese Medicine (TCM) herbal formula developed as a granule for the treatment of stable chronic obstructive pulmonary disease (COPD) complicated by chronic respiratory failure (CRF). The formula is designed based on the TCM principles of supplementing Qi (Yiqi), promoting blood circulation (Huoxue), and resolving phlegm (Huatan). It is typically used as an adjunctive therapy to standard Western medicine to reduce mortality, decrease acute exacerbations, and improve the quality of life in patients with severe respiratory conditions. A Phase 3 clinical trial sponsored by Peking University People's Hospital has evaluated its efficacy and safety in this patient population, specifically focusing on its ability to reduce mortality in patients with COPD and chronic respiratory failure.
- Other names
- Yiqi Huoxue Huatan formulaYiqi Huoxue Huatan granule
02
Targets
CTNNB1 (Beta-catenin)EGFR (Epidermal growth factor receptor)HIF1A (Hypoxia-inducible factor 1-alpha)IL-6 (Interleukin 6)MMP9 (Matrix metalloproteinase-9)NF-κBSTAT3 (Signal Transducer and Activator of Transcription 3)TLR4 (Toll-like receptor 4)TP53 (Cellular Tumor Antigen p53 R175H)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)
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