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Yiqi Huoxue Jiedu formula
- Development stage
- Phase 1
- Lead developer
- Beijing University of Chinese Medicine East Hospital
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Yiqi Huoxue Jiedu formula is a traditional Chinese medicine (TCM) multi-herbal compound designed to "tonify qi," "activate blood circulation," and "remove toxins." It is used as an adjunctive therapy in various diseases, including stable coronary heart disease, antibiotic-resistant pneumonia, and certain cancers. The formulation typically contains multiple herbs with purported anti-inflammatory, immunomodulatory, and cytoprotective effects. Mechanistically, preclinical studies suggest it may inhibit inflammatory cytokine production (such as IL-1β, IL-6, TNF-α), suppress NLRP3 inflammasome activation in immune cells (PBMCs), and repress Drp1-dependent mitochondrial fission to reduce tissue inflammation and damage[1][9][10]. Clinical trials are ongoing for several indications.
- Brand names
- Yiqihuoxuejiedu Formula
- Other names
- Yiqi Huoxue Jiedu RecipeYHJDYiqi Huoxue Jiedu decoction
02
Targets
DNM1L (Dynamin-related protein 1)IL-6 (Interleukin 6)TNFA (Tumor necrosis factor alpha (soluble))NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)
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