Drug intelligence / Profile preview

Yiqi Huoxue Jiedu formula

Development stage
Phase 1
Lead developer
Beijing University of Chinese Medicine East Hospital
Modality
Small Molecules
Administration
Oral
01

Overview

Yiqi Huoxue Jiedu formula is a traditional Chinese medicine (TCM) multi-herbal compound designed to "tonify qi," "activate blood circulation," and "remove toxins." It is used as an adjunctive therapy in various diseases, including stable coronary heart disease, antibiotic-resistant pneumonia, and certain cancers. The formulation typically contains multiple herbs with purported anti-inflammatory, immunomodulatory, and cytoprotective effects. Mechanistically, preclinical studies suggest it may inhibit inflammatory cytokine production (such as IL-1β, IL-6, TNF-α), suppress NLRP3 inflammasome activation in immune cells (PBMCs), and repress Drp1-dependent mitochondrial fission to reduce tissue inflammation and damage[1][9][10]. Clinical trials are ongoing for several indications.

Brand names
Yiqihuoxuejiedu Formula
Other names
Yiqi Huoxue Jiedu RecipeYHJDYiqi Huoxue Jiedu decoction
02

Targets

DNM1L (Dynamin-related protein 1)IL-6 (Interleukin 6)NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)TNFA (Tumor necrosis factor alpha (soluble))

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