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Yiqi Huoxue Zhitong Recipe
- Development stage
- Preclinical
- Lead developer
- Science and Technology Project for Social Development in Zhuhai
- Administration
- Oral
01
Overview
Yiqi Huoxue Zhitong Recipe is a traditional Chinese medicine (TCM) formula designed to invigorate Qi, activate blood circulation, remove blood stasis, and alleviate pain ('Zhitong'). It is being investigated for its effects on myocardial perfusion and inflammatory factors in patients with coronary heart disease after percutaneous coronary intervention. Its therapeutic actions are believed to involve mechanisms such as activating autophagy, inhibiting apoptosis and endoplasmic reticulum stress, and modulating inflammatory and prothrombotic pathways.
- Other names
- Yiqi Huoxue Zhitong granuleYiqi Huoxue GranuleYiqi Huoxue Recipe
02
Targets
AMPK (Adenosine monophosphate–activated protein kinase)PIK3C3 (PI3K class III)MAPK3 (Mitogen-activated protein kinase 1)KLF2 (Krüppel-like factor 2)NF-κBPAI-1 (Plasminogen activator inhibitor type 1)F2R (Protease-activated receptor 1)SOX9 (SRY-box transcription factor 9)F3 (Tissue factor)USP13 (Ubiquitin-specific peptidase 13)UCP2 (Uncoupling protein 2)MAPK14 (p38 mitogen-activated protein kinase alpha)CTNNB1 (Beta-catenin)
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