Drug intelligence / Profile preview

Yiqi Jiedu compound

Development stage
Preclinical
Lead developer
Longhua Hospital Shanghai University of Traditional Chinese Medicine
Administration
Oral
01

Overview

Yiqi Jiedu compound is a traditional Chinese medicine formula being investigated for its anti-cancer properties. It is the subject of a clinical study in combination with the checkpoint inhibitor pembrolizumab for the treatment of chemotherapy-resistant non-small cell lung cancer (NSCLC). [1] Preclinical research in mouse models of hepatocellular carcinoma (HCC) has shown that the formula can inhibit tumor growth, reduce tumor weight and volume, and increase tumor cell apoptosis. [1] The mechanism of action is thought to involve immunomodulation of the tumor microenvironment. Specifically, it has been observed to promote the polarization of M1 macrophages and inhibit the overactivation of the NF-κB signaling pathway, thereby enhancing anti-tumor immunity. [1]

Other names
Yiqi Jiedu Formula益气解毒方
02

Targets

MAPK14 (p38 mitogen-activated protein kinase alpha)JNK (Mitogen-activated protein kinase kinase kinase family)MAPK3 (Mitogen-activated protein kinase 1)

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