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Yiqi Jiedu Tongluo

Development stage: Preclinical
Lead developer: Shanghai Pulmonary Hospital, Tongji University
Administration: Oral

Overview

Yiqi Jiedu Tongluo is a Traditional Chinese Medicine (TCM) formula, often prepared as a decoction. It is investigated as an adjunctive therapy in oncology, particularly for advanced non-small cell lung cancer where it aims to delay targeted drug resistance when combined with EGFR-TKIs. Additionally, it has been studied in advanced esophageal squamous cell carcinoma in combination with Western chemotherapy regimens (camrelizumab, apatinib, and S-1), demonstrating potential to improve Traditional Chinese Medicine syndromes, enhance patient quality of life, prolong survival, and mitigate adverse effects such as nausea, vomiting, diarrhea, and fatigue associated with the conventional treatments. While its precise molecular mechanism of action is not fully elucidated in the provided context, its therapeutic role appears to involve modulating the body's response to cancer and conventional therapies.

Other names: Yiqi Jiedu Tongluo DecoctionYiqi Jiedu Tongluo Prescription益气解毒通络方

Targets

IL1B (Interleukin-1 beta)ICAM1 (Intercellular Adhesion Molecule 1)ESR1 (ERα)TP53 (Cellular Tumor Antigen p53 R175H)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)TGFB1 (Transforming growth factor Beta-1 proprotein)MMP2 (Matrix metalloproteinase-2)CASP3 (Caspase-3)

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