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Yiqi Kaimi Recipe is a traditional Chinese medicine (TCM) herbal compound used primarily for the treatment of functional constipation. It is formulated from multiple herbs and has been shown in preclinical and clinical studies to promote gastrointestinal motility by increasing the contraction frequency and amplitude of colonic smooth muscle. Mechanistically, it modulates levels of substance P proteins and neuronal nitric oxide synthase (NOS1) in the enteric plexus, enhancing intestinal peristalsis[1][2][3][5]. The recipe is believed to act through regulation of protein phosphorylation pathways that affect gut motility[2]. It is typically used as part of integrative therapy for chronic or functional constipation.
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