Drug intelligence / Profile preview

Yiqi Yangyin Decoction

Development stage
Unknown
Lead developer
Longhua Hospital Shanghai University of Traditional Chinese Medicine
Administration
Oral
01

Overview

Yiqi Yangyin Decoction (YYD) is a traditional Chinese medicine (TCM) herbal formulation developed by Longhua Hospital, Shanghai University of Traditional Chinese Medicine. It is composed of seven herbs: *Panax ginseng* (Ren Shen), *Polygonati Rhizoma* (Huang Jing), *Ophiopogon japonicus* (Mai Dong), *Lilii Bulbus* (Bai He), *Adenophorae Radix* (Nan Sha Shen), *Trichosanthis Radix* (Tian Hua Fen), and *Agrimonia eupatoria* (Xian He Cao) at a specific ratio of 4:5:5:10:5:5:10. YYD is primarily used in the treatment and prevention of non-small cell lung cancer (NSCLC). It is designed to replenish Qi and nourish Yin, and clinical research focuses on its ability to prevent the cancerous progression of ground-glass opacities (GGO) following surgery for early-stage lung cancer. Network pharmacology suggests it modulates multiple pathways involved in tumor cell proliferation, invasion, and migration.

Other names
Yiqi Yangyin Recipe
02

Targets

MEKEGFR T790M (Epidermal growth factor receptor T790M mutant)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)

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