Drug intelligence / Profile preview

yiqi yangyin quyu

Development stage
Unknown
Lead developer
The Second Affiliated Hospital of Zhejiang Chinese Medicine University
Modality
Small Molecules
Administration
Oral
01

Overview

Yiqi Yangyin Quyu is a Traditional Chinese Medicine (TCM) formula developed by the Second Affiliated Hospital of Zhejiang Chinese Medical University (also known as Xinhua Hospital of Zhejiang Province) specifically for the treatment of primary Sjogren's syndrome (pSS). The formula is designed based on the TCM therapeutic principles of supplementing Qi (Yiqi), nourishing Yin (Yangyin), and removing blood stasis (Quyu), which target the underlying pathology of Qi-Yin deficiency and blood stasis common in pSS patients. Clinical research indicates that the formula effectively alleviates symptoms of xerostomia (dry mouth) and xerophthalmia (dry eyes) while reducing systemic inflammatory markers such as erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and immunoglobulin G (IgG). Mechanistically, it is thought to modulate the immune response by inhibiting pro-inflammatory cytokines and potentially upregulating water channel proteins in the salivary and lacrimal glands.

Other names
Yiqi Yangyin Quyu GranuleYiqi Yangyin Quyu DecoctionYiqi Yangyin Quyu Formula益气养阴祛瘀方益气养阴祛瘀颗粒
02

Targets

IL-6 (Interleukin 6)TNFA (Tumor necrosis factor alpha (soluble))BAFF (Tumor necrosis factor ligand superfamily member 13B)IL1B (Interleukin-1 beta)

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