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Yishen Daluo Yin

Development stage
Preclinical
Administration
Oral
01

Overview

Yishen Daluo Yin is a multi-herb traditional Chinese medicine (TCM) decoction/formula designed as a **combination therapy**. Its main reported uses are in the management of neurological and autoimmune diseases, most notably **multiple sclerosis** (MS). Its primary active components, identified through network pharmacology, include **quercetin** and **kaempferol**. Mechanistically, Yishen Daluo Yin exerts neuroprotective, anti-inflammatory, and immunomodulatory effects. It modulates several signaling pathways—such as **MAPK**, **AGE-RAGE**, **IL-17 signaling**, and neuroactive ligand-receptor interactions—targets inflammation, oxidative stress, cellular apoptosis, and regulates neuronal death and microglial activity. It exhibits a multi-target, multi-pathway mode of action typical for complex TCM decoctions[8][9].

Other names
Yishen Daluo decoctionYishen Daluo Yin decoctionYSDLD
02

Targets

IL-6 (Interleukin 6)VEGFA (Vascular endothelial growth factor A)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)TNFA (Tumor necrosis factor alpha (soluble))IL1B (Interleukin-1 beta)

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