Drug intelligence / Profile preview

yishen huazhuo decoction

Development stage
Preclinical
Lead developer
Tianjin Institute of Pharmaceutical Research
Administration
Oral
01

Overview

Yishen Huazhuo decoction, also known as Ranmaijian, is a Traditional Chinese Medicine (TCM) formulation developed by Longhua Hospital, Shanghai University of Traditional Chinese Medicine. It is specifically designed to treat atherosclerosis, particularly in patients presenting with the Kidney Deficiency and Phlegm-Turbidity syndrome according to TCM diagnostic criteria. The decoction is typically administered as an adjunctive therapy alongside standard Western medical treatments, such as statins, to inhibit the progression of carotid atherosclerosis, reduce carotid intima-media thickness, and stabilize atherosclerotic plaques. Its therapeutic mechanism is based on the TCM principles of tonifying the kidney and resolving turbidity to improve vascular health and lipid metabolism.

Other names
Yishen Huazhuo decoctionRanmaijian
02

Targets

Aβ42 (Amyloid-beta peptide 1-42)Core autophagy machinery (ATG machinery)TREM2 (Triggering receptor expressed on myeloid cells 2)SPI1 (PU.1)

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