Drug intelligence / Profile preview

Yishen Jiangzhuo therapy

Development stage
Unknown
Lead developer
Tianjin Institute of Pharmaceutical Research
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Yishen Jiangzhuo therapy (YJG) is a Traditional Chinese Medicine (TCM) multi-herb granule formulation developed for the treatment of renal anemia and chronic kidney disease (CKD), particularly in non-dialysis patients at stages 3–4. The formulation consists of a complex botanical mixture including *Radix Pseudostellariae* (Taizishen), *Poria* (Fuling), *Rhizoma Atractylodis Macrocephalae* (Baizhu), *Radix Astragali Mongolici* (Huangqi), *Herba Taxilli Chinensis* (Sangjisheng), *Fructus Mori* (Sangshen), *Radix et Rhizoma Rhei Palm* (Dahuang), and *Herba Serissae Japonicae* (Liuyuexue). It is primarily studied by the Hebei Provincial Administration of Traditional Chinese Medicine as an add-on to standard Western medical care. Its therapeutic effects are attributed to the synergistic action of its multiple herbal constituents, which have been shown to influence immunity, bone metabolism, fibroblast growth factor 23 (FGF23) levels, and erythropoiesis-related parameters.

Other names
Yishen Jiangzhuo Granule
02

Targets

TGFB1 (Transforming growth factor Beta-1 proprotein)RK (Ribokinase)MAPK3 (Mitogen-activated protein kinase 1)

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