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Yishen Paidu Formula

Development stage: Preclinical
Lead developer: Huazhong University of Science and Technology
Modality: Implantable Devices → Device-based Delivery → Drug Delivery Systems, Transdermal Patches → Device-based Delivery → Drug Delivery Systems, Inhalation Devices → Device-based Delivery → Drug Delivery Systems
Administration: Oral

Overview

Yishen Paidu Formula is a Traditional Chinese Medicine (TCM) herbal combination primarily developed by Wuhan Union Hospital for the treatment of Chronic Kidney Disease (CKD). It is composed of four key herbs: Rheum officinale, Astragalus membranaceus, Bombyx batryticatus, and Hirudo. According to TCM principles, this formula works by nourishing Qi and kidney, ascending lucidity and descending turbidity, activating blood circulation, and removing blood stasis. Modern pharmacological studies suggest that its therapeutic effects in CKD are partly mediated through the inhibition of the PI3K/AKT/mTOR signaling pathway, contributing to its anti-inflammatory, anti-fibrotic, and kidney-protective properties.

Other names: 益肾排毒方Yishen Paidu PillsYishen Paidu Decoction

Targets

AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)

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