Drug intelligence / Profile preview

Yishen Xiezhuo Fang

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral
01

Overview

Yishen Xiezhuo Fang is a traditional Chinese medicine (TCM) granule formulation used in the treatment of chronic kidney disease (CKD), particularly in patients with diabetes-related CKD. It is designed to tonify the kidneys, promote diuresis, and eliminate dampness and turbidity. Clinical studies have shown that when combined with Western medications such as valsartan, it can significantly reduce urinary microalbuminuria and serum creatinine, improve glomerular filtration rate (GFR), lower D-dimer and fibrinogen levels, alleviate clinical symptoms of diabetic CKD patients, enhance quality of life, improve renal microcirculation and function, and reduce proteinuria[1][7]. The mechanism of action is believed to involve multi-targeted protection of renal function through TCM principles rather than a single molecular target.

Other names
益肾泄浊方益肾泄浊方颗粒剂
02

Targets

NF-κBGSDMD (Gasdermin D)IL18 (Interleukin-18)CASP1 (Caspase-1)NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)

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