Drug intelligence / Profile preview

yishen zengmo tang

Development stage
Unknown
Lead developer
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
Administration
Oral
01

Overview

Yishen Zengmo Tang is a Traditional Chinese Medicine (TCM) herbal decoction formulated to address thin endometrium and impaired endometrial receptivity, particularly in the context of assisted reproductive technology (ART). The formula typically comprises a combination of herbs such as Rehmannia glutinosa, Cuscuta chinensis, and Angelica sinensis, which are traditionally utilized to tonify the kidney and nourish the blood. Mechanistically, the formula is hypothesized to promote endometrial proliferation and angiogenesis by modulating the expression of estrogen receptors (ER), progesterone receptors (PR), and vascular endothelial growth factor (VEGF), thereby improving the uterine environment for embryo implantation. Clinical studies in China have evaluated its efficacy in increasing endometrial thickness and improving clinical pregnancy rates in patients undergoing in vitro fertilization (IVF).

Other names
益肾增膜汤Yishen Zengmo Decoction
02

Targets

ER (Estrogen receptor)VEGFA (Vascular endothelial growth factor A)PR (Progesterone receptor)

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