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Yishen Zhishuang Granules
- Development stage
- Unknown
- Lead developer
- Shuguang Hospital
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Yishen Zhishuang Granules (often identified in clinical literature as Yishen Zhishuai Granules) is a Traditional Chinese Medicine (TCM) compound formula developed by Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, specifically by the research team led by Professor He Liqun. It is primarily indicated for the treatment of IgA nephropathy (IgAN) and chronic kidney disease (CKD). The formula is designed to tonify the kidney, clear heat, and resolve stasis, with the clinical goal of reducing proteinuria and hematuria while stabilizing renal function. Pharmacologically, it has been shown to inhibit the TGF-β1/Smad signaling pathway, which is a key driver of renal fibrosis and glomerulosclerosis. It also exerts immunomodulatory effects by reducing the production of inflammatory cytokines and potentially affecting the mucosal immune system's production of galactose-deficient IgA1 (Gd-IgA1).
- Brand names
- Yishen Zhishuang Granules
- Other names
- 益肾止爽颗粒Yishen Zhishuai Granules益肾止衰颗粒Yishen Zhishuai
02
Targets
SMAD3 (SMAD family member 3)TGFB1 (Transforming growth factor Beta-1 proprotein)
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