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Yisheng Granules
- Development stage
- Unknown
- Lead developer
- Tianjin Institute of Pharmaceutical Research
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Yisheng Granules is a Traditional Chinese Medicine (TCM) formulation primarily indicated for the treatment of chronic pelvic inflammatory disease (PID) and associated chronic pelvic pain. Developed and manufactured by Guizhou Yisheng Pharmaceutical, the drug is composed of several botanical extracts, including *Leonurus japonicus* (Motherwort), *Angelica sinensis*, *Paeonia lactiflora*, *Cyperus rotundus*, *Poria cocos*, *Atractylodes macrocephala*, and *Glycyrrhiza uralensis*. Its therapeutic action is characterized by anti-inflammatory and analgesic properties. Mechanistically, the active phytochemicals (such as leonurine, paeoniflorin, and ferulic acid) inhibit the production of pro-inflammatory mediators, including tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and prostaglandin E2 (PGE2), while also modulating cyclooxygenase-2 (COX-2) activity. Additionally, the formulation is designed to improve pelvic microcirculation and promote the resolution of inflammatory adhesions and masses. In the context of TCM, it is used to address conditions categorized by "Qi deficiency and blood stasis."
- Brand names
- Yisheng Granules益生颗粒
- Other names
- Yisheng KeliYisheng Granule
02
Targets
TNFA (Tumor necrosis factor alpha (soluble))IL-6 (Interleukin 6)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)IL1B (Interleukin-1 beta)
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