Drug intelligence / Profile preview

Yishentongluo

Development stage
Preclinical
Lead developer
Beijing Hospital of Traditional Chinese Medicine
Administration
Oral
01

Overview

Yishentongluo is a Traditional Chinese Medicine (TCM) therapy developed by the Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, for the treatment of diabetic kidney disease (DKD). The therapy is based on the TCM principles of tonifying the kidney (Yishen) and dredging the collaterals (Tongluo). It typically involves the use of specific herbal prescriptions tailored to the disease stage, such as Baoshentongluo Xiaobai (focused on reducing proteinuria) and Baoshentongluo Xizhuo (focused on clearing metabolic waste or 'turbidity'). Clinical evaluation of Yishentongluo therapy often involves its use as an add-on to standard-of-care treatments like ACE inhibitors or ARBs to further improve renal function, reduce urinary albumin excretion, and slow the progression of kidney damage in diabetic patients.

Other names
Yishentongluo therapyYishentongluo prescriptionBaoshentongluo XiaobaiBaoshentongluo XizhuoBaosen Tongluo XiaobaiBaosen Tongluo Xizhuo
02

Targets

NFE2L2 (Nuclear factor (erythroid-derived 2)-like 2)BAX (Apoptosis regulator BAX)CASP3 (Caspase-3)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)CXCL12 (C-X-C motif chemokine ligand 12)NF-κBAR (Adrenergic receptors)

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